Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson’s Disease

Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson’s Disease

Background/Aims: Parkinson’s disease (PD) is a prevalent disease that leads to motor and cognitive disabilities, and oxidative stress (OS) injury was found to be related to the etiology of PD. Increasing evidence has shown that SHC3 is aberrantly expressed in neurons. The current study examines the...

Full description

Bibliographic Details
Main Authors: Jian Gong, Lei Zhang, Qian Zhang, Xiang Li, Xiang-Jun Xia, Yin-Yuan Liu, Qin-Shang Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
SHC3
Gene silencing
Parkinson’s disease
Oxidative stress injury
PI3K-AKT-FoxO signaling pathway
Online Access:https://www.karger.com/Article/FullText/493228

Internet

https://www.karger.com/Article/FullText/493228

Similar Items