Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer

Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer. Despite decades of intense investigation, treatment options remain limited, and rapid recurrence with distant metastases remains a significant challenge. Cancer cell-intrinsic production of cytokines such as...

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Bibliographic Details
Main Authors: Jeffrey C. Martin, Tatiane da Silva Fernandes, Kanita A. Chaudhry, Masanori Oshi, Scott I. Abrams, Kazuaki Takabe, Spencer R. Rosario, Anna Bianchi-Smiraglia
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Aryl hydrocarbon receptor
Triple-negative breast cancer
BRCA1/2 mutations
PARP inhibitors
cGAS-STING
Type I interferons
Online Access:https://doi.org/10.1038/s41598-024-54732-3

Internet

https://doi.org/10.1038/s41598-024-54732-3

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