A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum using a Cav1.4 knockout (KO) mouse and a knoc...

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Bibliographic Details
Main Authors: J Wesley Maddox, Gregory J Ordemann, Juan AM de la Rosa Vázquez, Angie Huang, Christof Gault, Serena R Wisner, Kate Randall, Daiki Futagi, Nihal A Salem, Dayne Mayfield, Boris V Zemelman, Steven DeVries, Mrinalini Hoon, Amy Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
ictidomys tridecemlineatus
calcium
photoreceptor
synapse
retina
Online Access:https://elifesciences.org/articles/94908

Internet

https://elifesciences.org/articles/94908

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