The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr<sup>−/−</sup> Mice with Obesity

The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr<sup>−/−</sup> Mice with Obesity

Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is approved by the FDA as a therapy to lower lipid levels in ad...

Full description

Bibliographic Details
Main Authors: Undral Munkhsaikhan, Young In Kwon, Amal M. Sahyoun, María Galán, Alexis A. Gonzalez, Karima Ait-Aissa, Ammaar H. Abidi, Adam Kassan, Modar Kassan
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
familial hypercholesteremia
HFD
lomitapide
cardiovascular function
vascular reactivity
Online Access:https://www.mdpi.com/2076-3921/12/6/1287

Internet

https://www.mdpi.com/2076-3921/12/6/1287

Similar Items