The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid

The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid

BackgroundAdenosine deaminase (ADA) via two isoenzymes, ADA1 and ADA2, regulates intra- and extracellular adenosine concentrations by converting it to inosine. In the central nervous system (CNS), adenosine modulates the processes of neuroinflammation and demyelination that together play a critical...

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Bibliographic Details
Main Authors: Barbara Kutryb-Zajac, Ada Kawecka, Fionä Caratis, Krzysztof Urbanowicz, Alicja Braczko, Tomomi Furihata, Bartosz Karaszewski, Ryszard T. Smolenski, Aleksandra Rutkowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
adenosine deaminase (ADA)
adenosine
multiple scleorsis (MS)
endothelium
ADA1
ADA2
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.998023/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.998023/full

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