Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer [version 2; referees: 3 approved]
Background: Germline mutations in the PALB2 gene are associated with the genetic disorder Fanconi anaemia and increased predisposition to cancer. Disease-associated variants are mainly protein-truncating mutations, whereas a few missense substitutions are reported to perturb its interaction with bre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wellcome
2018-01-01
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| Series: | Wellcome Open Research |
| Subjects: | |
| Online Access: | https://wellcomeopenresearch.org/articles/2-110/v2 |