A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

The CD4 binding site (CD4bs) on the envelope glycoprotein is a major site of vulnerability that is conserved among different HIV-1 isolates. Many broadly neutralizing antibodies (bNAbs) to the CD4bs belong to the VRC01 class, sharing highly restricted origins, recognition mechanisms and viral escape...

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Bibliographic Details
Main Authors: Natalia T Freund, Joshua A Horwitz, Lilian Nogueira, Stuart A Sievers, Louise Scharf, Johannes F Scheid, Anna Gazumyan, Cassie Liu, Klara Velinzon, Ariel Goldenthal, Rogier W Sanders, John P Moore, Pamela J Bjorkman, Michael S Seaman, Bruce D Walker, Florian Klein, Michel C Nussenzweig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4627763?pdf=render

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http://europepmc.org/articles/PMC4627763?pdf=render

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