PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phosphorylates 15 proteins encoded by PD-associat...

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Bibliographic Details
Main Authors: Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang, Helen I. Woodroof, David G. Campbell, Robert Gourlay, Lynn Burchell, Helen Walden, Thomas J. Macartney, Maria Deak, Axel Knebel, Dario R. Alessi, Miratul M. K. Muqit
Format: Article
Language:English
Published: The Royal Society 2012-01-01
Series:Open Biology
Subjects:
pink1
parkin
parkinson's disease
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120080

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120080

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