The circadian clock gene BMAL1 modulates autoimmunity features in lupus

The circadian clock gene BMAL1 modulates autoimmunity features in lupus

ObjectivesAn important pathogenic role for neutrophils in systemic lupus erythematosus (SLE) has been proposed. Neutrophils that lack brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1), one of the clock genes, are defective in aging and proinflammatory responses. We asses...

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Bibliographic Details
Main Authors: Shuichiro Nakabo, Donavon Sandoval-Heglund, Norio Hanata, Stephen Brooks, Victoria Hoffmann, Mingzeng Zhang, William Ambler, Zerai Manna, Elaine Poncio, Sarfaraz Hasni, Shamima Islam, Stefania Dell’Orso, Mariana J. Kaplan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
neutrophils
autoantibody
clock gene
Bmal1
April
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465185/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465185/full

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