A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis

SUMMARY The thrifty-gene hypothesis (TGH) posits that the modern genetic predisposition to obesity stems from a historical past where famine selected for genes that promote efficient fat deposition. It has been previously argued that such a scenario is unfeasible because under such strong selection...

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Bibliographic Details
Main Authors: John R. Speakman, Klaas R. Westerterp
Format: Article
Language:English
Published: The Company of Biologists 2013-01-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/1/236