MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke

MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke

ObjectiveBy exploring the effects of miR-29a-5p knockout on neurological damage after acute ischemic stroke, we aim to deepen understanding of the molecular mechanisms of post-ischemic injury and thus provide new ideas for the treatment of ischemic brain injury.MethodsmiR-29a-5p knockout rats and wi...

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Bibliographic Details
Main Authors: Fangfang Zhao, Haiping Zhao, Junfen Fan, Rongliang Wang, Ziping Han, Zhen Tao, Yangmin Zheng, Feng Yan, Yuyou Huang, Lei Yu, Xu Zhang, Xiaolong Qi, Lianfeng Zhang, Yumin Luo, Yuanwu Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
Ischemic stroke
miR-29a
microglia
astrocyte
glutamate
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.642079/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.642079/full

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