Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression

Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression

Abstract Background Glycolytic metabolic reprogramming is a phenomenon in which cells undergo altered metabolic patterns during malignant transformation, mainly involving various aspects of glycolysis, electron transport chain, oxidative phosphorylation, and pentose phosphate pathway. This reprogram...

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Bibliographic Details
Main Authors: Hongying Zhao, Rongke Jiang, Zhijing Feng, Xue Wang, Chunmei Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Gastric cancer
Cancer stem cells
Glycolytic metabolic reprogramming
Transcription factors
LHX9
Pyruvate kinase
Online Access:https://doi.org/10.1186/s12967-023-04658-7

Internet

https://doi.org/10.1186/s12967-023-04658-7

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