Synthesis of novel DOTA-/AAZTA-based bifunctional chelators: Solution thermodynamics, peptidomimetic conjugation, and radiopharmaceutical evaluation

Synthesis of novel DOTA-/AAZTA-based bifunctional chelators: Solution thermodynamics, peptidomimetic conjugation, and radiopharmaceutical evaluation

Bifunctional chelators (BFCs), which link metallic radionuclide and a targeting vector, are some of the most crucial components of metallic radionuclide-based radiopharmaceuticals for positron-emission computed tomography (PET) imaging. In this study, we designed and synthesized two versatile BFCs,...

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Bibliographic Details
Main Authors: Xiaoguang Liu, Lixing Chen, Yuying Li, Chuanchuan He, Xiaojuan Zhang, Huimin Zhou, Guangfa Bao, Xiaohua Zhu, Guangya Xiang, Xiang Ma
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
PET
68Ga
Bifunctional chelator
Prostrate-specific membrane antigen
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009058

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http://www.sciencedirect.com/science/article/pii/S0753332223009058

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