Advanced Cell Culture Models Illuminate the Interplay between Mammary Tumor Cells and Activated Fibroblasts

Advanced Cell Culture Models Illuminate the Interplay between Mammary Tumor Cells and Activated Fibroblasts

The interaction between tumor cells and activated fibroblasts determines malignant features of desmoplastic carcinomas such as rapid growth, progression towards a metastatic phenotype, and resistance to chemotherapy. On one hand, tumor cells can activate normal fibroblasts and even reprogram them in...

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Bibliographic Details
Main Authors: Martina Del Nero, Alessandro Colombo, Stefania Garbujo, Chiara Baioni, Linda Barbieri, Metello Innocenti, Davide Prosperi, Miriam Colombo, Luisa Fiandra
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
advanced cell culture models
triple-negative breast cancer
CAF-cancer cell crosstalk
TGF-β
PDGF
IL-6
Online Access:https://www.mdpi.com/2072-6694/15/9/2498

Internet

https://www.mdpi.com/2072-6694/15/9/2498

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