Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation

Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation

Alcohol consumption and obesity are known risk factors of steatohepatitis. Here, we report that the deficiency of CRAMP (cathelicidin-related antimicrobial peptide—gene name: <i>Camp</i>) is protective against a high-fat diet (HFD) plus acute alcohol (HFDE)-induced liver injury. HFDE mar...

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Bibliographic Details
Main Authors: Fengyuan Li, Jenny Chen, Yunhuan Liu, Zelin Gu, Mengwei Jiang, Lihua Zhang, Shao-Yu Chen, Zhongbin Deng, Craig J. McClain, Wenke Feng
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
cathelicidin
HFD plus alcohol
neutrophil
FGF21/adiponectin
adipose lipolysis
Online Access:https://www.mdpi.com/2073-4409/10/12/3333

Internet

https://www.mdpi.com/2073-4409/10/12/3333

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