Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy

Throughout the history of oncology research, tumor heterogeneity has been a major hurdle for the successful treatment of cancer. As a result of aberrant changes in the tumor microenvironment such as high mutational burden, hypoxic conditions and abnormal vasculature, several malignant subpopulations...

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Bibliographic Details
Main Authors: Nader El-Sayes, Alyssa Vito, Karen Mossman
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/4/806