Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS

Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS

BackgroundNeutrophil extracellular traps (NETs) can cause acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by inducing macrophage pyroptosis. The purpose of this study was to find out whether pretreatment of alpha-linolenic acid (ALA) could inhibit NETs-induced macrophage pyroptosi...

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Bibliographic Details
Main Authors: Chenchen Liu, Yu Zhou, Qing Tu, Liangfang Yao, Jinbao Li, Zhongwei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
sepsis
ARDS
NETs
pyrin
pyroptosis
alpha-linolenic acid (ALA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146612/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146612/full

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