Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the int...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Nature Portfolio
2019-11-01
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| Colección: | Nature Communications |
| Acceso en línea: | https://doi.org/10.1038/s41467-019-13213-2 |