Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the int...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13213-2 |
| _version_ | 1818991751859273728 |
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| author | Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen |
| author_facet | Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen |
| author_sort | Tommi Kotila |
| collection | DOAJ |
| description | The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits. |
| first_indexed | 2024-12-20T20:15:15Z |
| format | Article |
| id | doaj.art-a7e7c8a65f604e56a1377651d6ef54c8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:15:15Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a7e7c8a65f604e56a1377651d6ef54c82022-12-21T19:27:44ZengNature PortfolioNature Communications2041-17232019-11-0110111410.1038/s41467-019-13213-2Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilinTommi Kotila0Hugo Wioland1Giray Enkavi2Konstantin Kogan3Ilpo Vattulainen4Antoine Jégou5Guillaume Romet-Lemonne6Pekka Lappalainen7HiLIFE Institute of Biotechnology, University of HelsinkiUniversité de Paris, CNRS, Institut Jacques MonodDepartment of Physics, University of HelsinkiHiLIFE Institute of Biotechnology, University of HelsinkiDepartment of Physics, University of HelsinkiUniversité de Paris, CNRS, Institut Jacques MonodUniversité de Paris, CNRS, Institut Jacques MonodHiLIFE Institute of Biotechnology, University of HelsinkiThe cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits.https://doi.org/10.1038/s41467-019-13213-2 |
| spellingShingle | Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin Nature Communications |
| title | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin |
| title_full | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin |
| title_fullStr | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin |
| title_full_unstemmed | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin |
| title_short | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin |
| title_sort | mechanism of synergistic actin filament pointed end depolymerization by cyclase associated protein and cofilin |
| url | https://doi.org/10.1038/s41467-019-13213-2 |
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