Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson’s Disease

Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia (BG) circuitry. Dopamine (DA) depletion in experimental PD models leads to the pathological strengthening of pallido-subthalamic synaptic connections, contributing to the emergence of abno...

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Bibliographic Details
Main Authors: Mojtaba Madadi Asl, Atefeh Asadi , Jamil Enayati , Alireza Valizadeh 
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Physiology
Subjects:
inhibitory spike-timing-dependent plasticity
synaptic plasticity
parkinson’s disease
synchronization
basal ganglia
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.915626/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.915626/full

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