Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma

Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma

Abstract Background Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress. Cells cope with ER stress by activating the unfolded protein response (UPR), a signaling pathway...

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Bibliographic Details
Main Authors: Fernanda Dittrich Oliveira, Rafael Paschoal de Campos, Luiza Cherobini Pereira, Lisiane B. Meira, Guido Lenz
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Translational Medicine Communications
Subjects:
Glioblastoma
Unfolded protein response
Endoplasmic reticulum stress
Transcriptomics
Single cell RNA-sequencing
Online Access:https://doi.org/10.1186/s41231-024-00164-0

Internet

https://doi.org/10.1186/s41231-024-00164-0

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