Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

Transthyretin (TTR) is one of thirty non-homologous proteins whose misfolding, dissociation, aggregation, and deposition is linked to human amyloid diseases. Previous studies have identified that TTR amyloidogenesis can be inhibited through stabilization of the native tetramer state by small molecul...

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Bibliographic Details
Main Authors: Satheesh K Palaninathan, Nilofar N Mohamedmohaideen, Elisabetta Orlandini, Gabriella Ortore, Susanna Nencetti, Annalina Lapucci, Armando Rossello, Joel S Freundlich, James C Sacchettini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2709434?pdf=render

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http://europepmc.org/articles/PMC2709434?pdf=render

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