JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases

Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing a critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis and the Janus kin...

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Bibliographic Details
Main Authors: Yimeng Dai, Chunguo Cui, Dan Jiao, Xuewei Zhu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Cell International
Subjects:
Online Access:https://doi.org/10.1186/s12935-025-03681-6