Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma

Statin-Sensitive Akt1/Src/Caveolin-1 Signaling Enhances Oxidative Stress Resistance in Rhabdomyosarcoma

Identifying the molecular mechanisms underlying radioresistance is a priority for the treatment of RMS, a myogenic tumor accounting for approximately 50% of all pediatric soft tissue sarcomas. We found that irradiation (IR) transiently increased phosphorylation of Akt1, Src, and Cav1 in human RD and...

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Bibliographic Details
Main Authors: Silvia Codenotti, Leonardo Sandrini, Delia Mandracchia, Luisa Lorenzi, Giovanni Corsetti, Maura Poli, Michela Asperti, Valentina Salvi, Daniela Bosisio, Eugenio Monti, Stefania Mitola, Luca Triggiani, Michele Guescini, Enrico Pozzo, Maurilio Sampaolesi, Stefano Gastaldello, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
Akt1
catalase
caveolin-1
radioresistance
rhabdomyosarcoma
Src
Online Access:https://www.mdpi.com/2072-6694/16/5/853

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https://www.mdpi.com/2072-6694/16/5/853

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