Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression

Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression

Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g. liraglutide), serotonin 2C (5-HT2CR; e.g, lorcas...

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Bibliographic Details
Main Authors: Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Molecular Metabolism
Subjects:
Lorcaserin
Liraglutide
Preproglucagon
Nucleus tractus solitarii
Brainstem
Serotonin 2C receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002344

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http://www.sciencedirect.com/science/article/pii/S2212877822002344

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