Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis

Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis

Abstract Background Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic secretion pathway (PSP) may enhance the risk for RP/CP in patients with CF...

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Main Authors: Valentina Maria Sofia, Cecilia Surace, Vito Terlizzi, Letizia Da Sacco, Federico Alghisi, Antonella Angiolillo, Cesare Braggion, Natalia Cirilli, Carla Colombo, Antonella Di Lullo, Rita Padoan, Serena Quattrucci, Valeria Raia, Giuseppe Tuccio, Federica Zarrilli, Anna Cristina Tomaiuolo, Antonio Novelli, Vincenzina Lucidi, Marco Lucarelli, Giuseppe Castaldo, Adriano Angioni
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Medicine
Subjects:
Cystic fibrosis
Recurrent/chronic pancreatitis
CFTR gene
Trypsin
Pancreatic pathways
Trans-heterozogosity
Online Access:http://link.springer.com/article/10.1186/s10020-018-0041-6

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http://link.springer.com/article/10.1186/s10020-018-0041-6

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