Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors

Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors

Abstract Cancer cells have altered cellular metabolism. Mutations in genes associated with key metabolic pathways (e.g., isocitrate dehydrogenase 1 and 2, IDH1/IDH2) are important drivers of cancer, including central nervous system (CNS) tumors. Therefore, we hypothesized that the abnormal metabolic...

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Bibliographic Details
Main Authors: Leomar Y. Ballester, Guangrong Lu, Soheil Zorofchian, Venkatrao Vantaku, Vasanta Putluri, Yuanqing Yan, Octavio Arevalo, Ping Zhu, Roy F. Riascos, Arun Sreekumar, Yoshua Esquenazi, Nagireddy Putluri, Jay-Jiguang Zhu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
CSF
Metabolites
Brain tumor
Glioma
Hydroxyglutarate
Liquid biopsy
Online Access:http://link.springer.com/article/10.1186/s40478-018-0588-z

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http://link.springer.com/article/10.1186/s40478-018-0588-z

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