Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma

Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma

Patients with high-risk non-metastatic renal cell carcinoma (RCC) are at risk of metastatic relapse following nephrectomy. Cabozantinib (CZ), a potent multitarget tyrosine kinase inhibitor, interferes with angiogenesis and immunosuppression associated with surgery-induced metastasis. Here, we explor...

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Bibliographic Details
Main Authors: Hye Won Lee, Hee Seung Seo, Seon-Yong Yeom, Se-Na Kim, Cho Rim Kim, Dae-Hwan Park, Wooram Park, Young Bin Choy, Chun Gwon Park, Seong Il Seo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
adjuvant
cabozantinib
drug delivery
enhanced permeability retention
nanoparticle
poly(lactic-co-glycolic acid)
Online Access:https://www.mdpi.com/1422-0067/23/20/12634

Internet

https://www.mdpi.com/1422-0067/23/20/12634

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