7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

Imbalances in bone formation and resorption cause osteoporosis. Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone (7,8-DHF), a plant-derived small molecular TrkB agonist, mimics the functions of BDNF. We show that both BDNF and...

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Bibliografiske detaljer
Main Authors: Fan Xue, Zhenlei Zhao, Yanpei Gu, Jianxin Han, Keqiang Ye, Ying Zhang
Format: Article
Sprog:English
Udgivet: eLife Sciences Publications Ltd 2021-07-01
Serier:eLife
Fag:
7,8-dihydroxyflavone
bone remodeling
osteoblasts
osteoclasts
ovariectomy rat model
Online adgang:https://elifesciences.org/articles/64872

Internet

https://elifesciences.org/articles/64872

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