Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes

Infectious diseases of the respiratory tract are one of the top causes of global morbidity and mortality with lower respiratory tract infections being the fourth leading cause of death. The respiratory mucosal (RM) route of vaccine delivery represents a promising strategy against respiratory infecti...

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Bibliographic Details
Main Authors: Vidthiya Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Anna Zganiacz, Xueya Feng, Matthew S. Miller, Mangalakumari Jeyanathan, Michael R. Thompson, Zhou Xing
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
respiratory mucosal immunization
intranasal
endotracheal
biodistribution
Adenovirus-vectored vaccine
Tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.860399/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.860399/full

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