Copper-catalyzed alkyne oxidation/Büchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones

Copper-catalyzed alkyne oxidation/Büchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones

Organic molecules containing seven-membered rings are important structural motifs for drug candidates, but the construction of seven-membered rings can be challenging through traditional cyclization pathways. Here, the authors report a copper-catalyzed alkyne oxidation and Büchner-type ring-expansio...

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Bibliographic Details
Main Authors: Xiao-Lei Jiang, Qing Liu, Kua-Fei Wei, Ting-Ting Zhang, Guang Ma, Xiu-Hong Zhu, Guang-Xin Ru, Lijie Liu, Lian-Rui Hu, Wen-Bo Shen
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-00840-6

Internet

https://doi.org/10.1038/s42004-023-00840-6

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