Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors

Structural Modifications on Chalcone Framework for Developing New Class of Cholinesterase Inhibitors

Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been considered one of the most privileged frameworks in the drug discovery process. Structurally, chalcones are α, β-unsaturated carbonyl functionalities with two aryl or heteroaryl units. Amongst the numerous pha...

Full description

Bibliographic Details
Main Authors:	Ginson George, Vishal Payyalot Koyiparambath, Sunitha Sukumaran, Aathira Sujathan Nair, Leena K. Pappachan, Abdullah G. Al-Sehemi, Hoon Kim, Bijo Mathew
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	International Journal of Molecular Sciences
Subjects:	chalcones acetylcholinesterase butyrylcholinesterase structure activity relationships
Online Access:	https://www.mdpi.com/1422-0067/23/6/3121

Similar Items

Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
by: Payyalot Koyiparambath Vishal, et al.
Published: (2021-06-01)

Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase
by: Sri Devi Sukumaran, et al.
Published: (2021-01-01)

Naturally Occurring Chalcones with Aggregation-Induced Emission Enhancement Characteristics
by: Iwona Budziak-Wieczorek, et al.
Published: (2023-04-01)

Characterization of placental cholinesterases and activity induction associated to environmental organophosphate exposure
by: S. Sánchez, et al.
Published: (2015-01-01)

Cholinesterase-targeting microRNAs identified in silico affect specific biological processes
by: Geula eHanin, et al.
Published: (2011-10-01)

Determination of cholinesterase inhibition potential of rose extract
by: Esra Şentürk, et al.
Published: (2018-10-01)

Cholinesterase inhibitors isolated from bilberry fruit
by: Kamila Borowiec, et al.
Published: (2014-11-01)

Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives
by: Rafaqat Hussain, et al.
Published: (2022-09-01)

Early appearance and possible roles of non-neuromuscular cholinesterases.
by: Carla eFalugi
Published: (2012-04-01)

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity
by: Anita Bosak, et al.
Published: (2017-01-01)

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
by: Jong Min Oh, et al.
Published: (2020-05-01)

A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease
by: Sultan Darvesh, et al.
Published: (2023-12-01)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
by: Keith D. Green, et al.
Published: (2018-12-01)

Association between cholinesterase activity and critical illness brain dysfunction
by: Christopher G. Hughes, et al.
Published: (2022-12-01)

Assessment of Physicochemical Quality, Antioxidant Content and Activity, and Inhibition of Cholinesterase between Unripe and Ripe Blueberry Fruit
by: Hyesung Hwang, et al.
Published: (2020-05-01)

Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs
by: Alicja Skrzypek, et al.
Published: (2022-12-01)

A Comprehensive Review of Cholinesterase Modeling and Simulation
by: Danna De Boer, et al.
Published: (2021-04-01)

Neuroprotective Effects of Blueberries through Inhibition on Cholinesterase, Tyrosinase, Cyclooxygenase-2, and Amyloidogenesis
by: Pari Samani, et al.
Published: (2023-01-01)

Cholinesterase Enzymes Inhibitors from the Leaves of Rauvolfia Reflexa and Their Molecular Docking Study
by: Vikneswaran Murugaiyah, et al.
Published: (2013-03-01)

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease
by: Rosa Purgatorio, et al.
Published: (2021-08-01)

The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies
by: Muhammad Mansha, et al.
Published: (2021-07-01)

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice
by: Andrea R. Durrant, et al.
Published: (2012-06-01)

Cholinesterases in Tripartite Neuromuscular Synapse
by: Konstantin A. Petrov, et al.
Published: (2021-12-01)

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase
by: Anne Loesche, et al.
Published: (2019-03-01)

Extraction of Antioxidants from Winemaking Byproducts: Effect of the Solvent on Phenolic Composition, Antioxidant and Anti-Cholinesterase Activities, and Electrochemical Behaviour
by: María José Jara-Palacios, et al.
Published: (2020-07-01)

Inhibitory Evaluation of Sulfonamide Chalcones on &#946;-Secretase and Acylcholinesterase
by: Dae Wook Kim, et al.
Published: (2012-12-01)

Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors
by: Martin Krátký, et al.
Published: (2021-11-01)

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms
by: Jana Zdarova-Karasova, et al.
Published: (2009-05-01)

In vivo cholinesterase sensitivity of gilthead seabream (Sparus aurata) exposed to organophosphate compounds: Influence of biological factors
by: M.G. Albendín, et al.
Published: (2021-02-01)

In vitro and in silico analysis of Solanum torvum fruit and methyl caffeate interaction with cholinesterases
by: Maha Aljabri, et al.
Published: (2023-10-01)

Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine–Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice
by: Rumyana Simeonova, et al.
Published: (2022-11-01)

7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies
by: Kamil Kuca, et al.
Published: (2013-02-01)

Phytochemical composition of Caesalpinia crista extract as potential source for inhibiting cholinesterase and β-amyloid aggregation: Significance to Alzheimer's disease
by: Kolambe Rajappa Chethana, et al.
Published: (2018-01-01)

Identification of Natural Compounds of the Apple as Inhibitors against Cholinesterase for the Treatment of Alzheimer’s Disease: An In Silico Molecular Docking Simulation and ADMET Study
by: Qazi Mohammad Sajid Jamal, et al.
Published: (2023-03-01)

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
by: Rani Sasidharan, et al.
Published: (2021-01-01)

Synthesis and Cholinesterase Inhibitory Potency of 2,3-Indolo-oleanolic Acid and Some Related Derivatives
by: Anastasiya V. Petrova, et al.
Published: (2023-10-01)

Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
by: Kaitlyn N. Alcorn, et al.
Published: (2024-12-01)

Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts
by: Tereza Padrtova, et al.
Published: (2017-11-01)

Synthesis, Biological Evaluation and Docking Studies of Chalcone and Flavone Analogs as Antioxidants and Acetylcholinesterase Inhibitors
by: Laura Díaz-Rubio, et al.
Published: (2019-01-01)

Natural Inhibitors of Cholinesterases: Chemistry, Structure–Activity and Methods of Their Analysis
by: Natalia Smyrska-Wieleba, et al.
Published: (2023-02-01)