The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.

The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.

Microbial agents can aggravate inflammatory diseases, such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). An example is pertussis toxin (PTX), a bacterial virulence factor commonly used as an adjuvant to promote EAE, but whose mechanism of action is...

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Bibliographic Details
Main Authors: Aline Dumas, Nathalie Amiable, Juan Pablo de Rivero Vaccari, Jae Jin Chae, Robert W Keane, Steve Lacroix, Luc Vallières
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4038594?pdf=render

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http://europepmc.org/articles/PMC4038594?pdf=render

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