Polyprotein Processing as a Determinant for in Vitro Activity of Semliki Forest Virus Replicase

Polyprotein Processing as a Determinant for in Vitro Activity of Semliki Forest Virus Replicase

Semliki Forest virus (SFV) is an arthropod-borne alphavirus that induces membrane invaginations (spherules) in host cells. These harbor the viral replication complexes (RC) that synthesize viral RNA. Alphaviruses have four replicase or nonstructural proteins (nsPs), nsP1–4, expressed as polyprotein...

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Bibliographic Details
Main Authors: Maija K. Pietilä, Irina C. Albulescu, Martijn J. van Hemert, Tero Ahola
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Viruses
Subjects:
alphavirus
Semliki Forest virus
nonstructural protein
polymerase
replication complex
in vitro replication
RNA synthesis
Online Access:https://www.mdpi.com/1999-4915/9/10/292

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https://www.mdpi.com/1999-4915/9/10/292

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