Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics

Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics

The granulin protein (also known as, and hereafter referred to as, progranulin) is a secreted glycoprotein that contributes to overall brain health. Heterozygous loss-of-function mutations in the gene encoding the progranulin protein (Granulin Precursor, GRN) are a common cause of familial frontotem...

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Bibliographic Details
Main Authors: Terri L. Petkau, Benjamin Life, Ge Lu, Jasmine Yang, Oriol Fornes, Wyeth Wasserman, Elizabeth M. Simpson, Blair R. Leavitt
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Neurobiology of Disease
Subjects:
Progranulin
Frontotemporal dementia
Transgenic mice
Progranulin over-expression
Bacterial artificial chromosome
Hprt-targeted mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000632

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http://www.sciencedirect.com/science/article/pii/S0969996121000632

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