Investigation of CRS-associated cytokines in CAR-T therapy with meta-GNN and pathway crosstalk

Investigation of CRS-associated cytokines in CAR-T therapy with meta-GNN and pathway crosstalk

Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy is a new and efficient cellular immunotherapy. The therapy shows significant efficacy, but also has serious side effects, collectively known as cytokine release syndrome (CRS). At present, some CRS-related cytokines and their roles...

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Bibliographic Details
Main Authors: Zhenyu Wei, Qi Cheng, Nan Xu, Chengkui Zhao, Jiayu Xu, Liqing Kang, Xiaoyan Lou, Lei Yu, Weixing Feng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Bioinformatics
Subjects:
CAR-T therapy
Cytokine release syndrome
Meta-learning graph neural network
Functional enrichment analysis
Pathway crosstalk
Online Access:https://doi.org/10.1186/s12859-022-04917-2

Internet

https://doi.org/10.1186/s12859-022-04917-2

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