TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation

TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation

Abstract Background Tumor cell metabolic reprogramming is crucial for the malignant behavior of cancer cells by promoting their proliferation. However, little is known on how transient receptor potential 7 (TRPM7) modulates metabolic reprogramming in ovarian cancer. Methods The effects of TRPM7 sile...

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Bibliographic Details
Main Authors: Yongchang Chen, Lu Liu, Longzheng Xia, Nayiyuan Wu, Ying Wang, He Li, Xue Chen, Xiaoye Zhang, Zhaoyi Liu, Miaochen Zhu, Qianjin Liao, Jing Wang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TRPM7
AMPK
HIF-1α
Glycolysis
Oxidative phosphorylation
Ubiquitination
Online Access:https://doi.org/10.1186/s13046-022-02252-1

Internet

https://doi.org/10.1186/s13046-022-02252-1

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