Structure-Antitumor Activity Relationships of Aza- and Diaza-Anthracene-2,9,10-Triones and Their Partially Saturated Derivatives

Structure-Antitumor Activity Relationships of Aza- and Diaza-Anthracene-2,9,10-Triones and Their Partially Saturated Derivatives

The 1,8-Diazaanthracene-2,9,10-triones, their 5,8-dihydro derivatives, and 1,8-diazaanthracene-2,7,9,10-tetraones, structurally related to the diazaquinomycin family of natural products, were synthesized in a regioselective fashion employing Diels–Alder strategies. These libraries were studied for t...

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Bibliographic Details
Main Authors: Carmen Avendaño, Pilar López-Alvarado, José María Pérez, Miguel Ángel Alonso, Eva Pascual-Alfonso, Miriam Ruiz-Serrano, J. Carlos Menéndez
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
azaanthracene-2,9,10-triones
diazaanthracene-2,9,10-triones
hetero Diels–Alder reactions
antitumor activity
diazaquinomycins
marcanines
Online Access:https://www.mdpi.com/1420-3049/29/2/489

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https://www.mdpi.com/1420-3049/29/2/489

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