Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants

Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants

Organ fibrosis, particularly of the lungs, causes significant morbidity and mortality. Effective treatments are needed to reduce the health burden. A fragment of the carboxyl-terminal end of collagen XVIII/endostatin reduces skin and lung fibrosis. This fragment was modified to facilitate its produc...

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Bibliographic Details
Main Authors: Logan Mlakar, Sara M. Garrett, Tomoya Watanabe, Matthew Sanderson, Tetsuya Nishimoto, Jonathan Heywood, Kristi L. Helke, Joseph M. Pilewski, Erica L. Herzog, Carol Feghali-Bostwick
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
endostatin
peptides
bleomycin
fibrosis
idiopathic pulmonary fibrosis
systemic sclerosis
Online Access:https://www.mdpi.com/2227-9059/10/11/2861

Internet

https://www.mdpi.com/2227-9059/10/11/2861

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