PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy

PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy

The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy. To address this, DSPE-mPEG2000 and Cremophor EL are two of the m...

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Bibliographic Details
Main Authors: Jun Zeng, Chen Li, Xing Duan, Fuyue Liu, Anqin Li, Chunhan Luo, Li Jia, Yifang Gan, Lu Yan, Yaxin Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
sn38
lipophilic prodrug
nanomedicine
cremophor el
pegylation
Online Access:http://dx.doi.org/10.1080/10717544.2019.1587045

Internet

http://dx.doi.org/10.1080/10717544.2019.1587045

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