Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy

The treatment of melanoma has been revolutionized by new therapies targeting MAPK signaling or the immune system. Unfortunately these therapies are hindered by either primary resistance or the development of acquired resistance. Resistance mechanisms involving somatic mutations in genes associated w...

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Bibliographic Details
Main Authors: Stuart J Gallagher, Jessamy C Tiffen, Peter Hersey
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/7/4/0870