Deletion of ultraconserved elements yields viable mice.
Ultraconserved elements have been suggested to retain extended perfect sequence identity between the human, mouse, and rat genomes due to essential functional properties. To investigate the necessities of these elements in vivo, we removed four noncoding ultraconserved elements (ranging in length fr...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-09-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1964772?pdf=render |