Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibody termed mAb P-4G2, which neutralizes the zoonotic...

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Bibliographic Details
Main Authors: Ilona Rissanen, Robert Stass, Stefanie A Krumm, Jeffrey Seow, Ruben JG Hulswit, Guido C Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J Doores, Juha T Huiskonen, Thomas A Bowden
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
hantavirus
structure
neutralizing antibody
viral fusion
glycoprotein
Online Access:https://elifesciences.org/articles/58242

Internet

https://elifesciences.org/articles/58242

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