Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD

Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD

ABSTRACTAlpha-synuclein (α-syn) pathology is the hallmark of Parkinson‘s disease (PD). The leucine-rich repeat kinase 2 (LRRK2) gene is a major-effect risk gene for sporadic PD (sPD). However, what environmental factors may trigger the formation of α-syn pathology in carriers of LRRK2 risk variants...

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Bibliographic Details
Main Authors: Dongxiao Liang, Han Liu, Ruoqi Jin, Renyi Feng, Jiuqi Wang, Chi Qin, Rui Zhang, Yongkang Chen, Jingwen Zhang, Junfang Teng, Beisha Tang, Xuebing Ding, Xuejing Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Parkinson’s disease
LRRK2
Escherichia coli
gene-environment interplay
α-synuclein pathology
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2276296

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https://www.tandfonline.com/doi/10.1080/19490976.2023.2276296

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