Infection and Activation of B Cells by Theiler’s Murine Encephalomyelitis Virus (TMEV) Leads to Autoantibody Production in an Infectious Model of Multiple Sclerosis

Infection and Activation of B Cells by Theiler’s Murine Encephalomyelitis Virus (TMEV) Leads to Autoantibody Production in an Infectious Model of Multiple Sclerosis

Theiler’s murine encephalomyelitis virus (TMEV) induces immune-mediated inflammatory demyelinating disease in susceptible mice that is similar to human multiple sclerosis (MS). In light of anti-CD20 therapies for MS, the susceptibility of B cells to TMEV infection is particularly important. In our s...

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Bibliographic Details
Main Authors: Young-Hee Jin, Charles X. Kim, Jocelin Huang, Byung S. Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
infectious immunity
virus
autoantibodies
demyelination
multiple sclerosis
Online Access:https://www.mdpi.com/2073-4409/9/8/1787

Internet

https://www.mdpi.com/2073-4409/9/8/1787

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