Evolution of tet(A) variant mediating tigecycline resistance in KPC-2-producing Klebsiella pneumoniae during tigecycline treatment

ABSTRACT: Objectives: This study investigated the underlying mechanism of the evolution of tigecycline resistance during treatment in a patient infected with Klebsiella pneumoniae harbouring blaKPC-2. Methods: A total of seven clonal K. pneumoniae strains were continuously isolated from a patient d...

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Bibliographic Details
Main Authors: Wenli Liao, Lingbo Wang, Xiangkuo Zheng, Ying Zhang, Tao Chen, Cui Zhou, Ye Xu, Lijiang Chen, Tieli Zhou
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716522000108