Hyperglycemia Impairs Acetylcholine-Induced Vasodilation of Retinal Arterioles Through Polyol Pathway–Independent Mechanisms in Rats

We previously reported that acetylcholine (ACh)–induced vasodilation of retinal arterioles is diminished in diabetic rats; however, the underlying mechanism(s) of this phenomenon has not been fully elucidated. To determine the role of the polyol pathway in the diabetes-induced retinal vascular dysfu...

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Bibliographic Details
Main Authors: Asami Mori, Orie Saigo, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319310023