Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica

Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica

Abstract Japanese encephalitis (JE) virus is a flavivirus causing encephalitis causing neurological damage. RNA-dependent-RNA-polymerase (RdRp) is responsible for genome replication making it excellent anti-viral target. In this study, the crystal structure of JE RdRp (jRdRp) and bioflavonoids repor...

Full description

Bibliographic Details
Main Authors: Vivek Dhar Dwivedi, Ankita Singh, Sherif Aly El-Kafraway, Thamir A. Alandijany, Arwa A. Faizo, Leena Hussein Bajrai, Mohammad Amjad Kamal, Esam Ibraheem Azhar
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96917-0

Internet

https://doi.org/10.1038/s41598-021-96917-0

Similar Items