The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of β-Thalassemia through Computational Methods

The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of β-Thalassemia through Computational Methods

β-Thalassemia is an inherited genetic disorder associated with β-globin chain synthesis, which ultimately becomes anemia. Adenosine-2,3-dialdehyde, by inhibiting arginine methyl transferase 5 (PRMT5), can induce fetal hemoglobin (HbF) levels. Hence, the materialization of PRMT5 inhibitors is conside...

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Bibliographic Details
Main Authors: Bishant Pokharel, Yuvaraj Ravikumar, Lavanyasri Rathinavel, Teera Chewonarin, Monsicha Pongpom, Wachiraporn Tipsuwan, Pimpisid Koonyosying, Somdet Srichairatanakool
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Molecules
Subjects:
β-thalassemia
PRMT5 inhibitors
fetal hemoglobin
molecular docking
dynamics
simulations
Online Access:https://www.mdpi.com/1420-3049/29/11/2662

Internet

https://www.mdpi.com/1420-3049/29/11/2662

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