Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology

Abstract Tau is a predominantly neuronal, soluble and natively unfolded protein that can bind and stabilize microtubules in the central nervous system. Tau has been extensively studied over several decades, especially in the context of neurodegenerative diseases where it can aberrantly aggregate to...

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Bibliographic Details
Main Authors: Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion, Stefan Prokop, Benoit I. Giasson
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-022-01394-9